Principal Software Architect University of Manchester, Department of Biology, Medicine & Health United Kingdom

About The Role:

The Cancer Research UK Manchester Institute (CRUK MI) has access to state of the art genomics, proteomics and imaging technology, which are together being used to advance our understanding of cancer. Our aim is to gain a greater understanding of the fundamental basis of how cancer develops and apply that knowledge to develop new diagnostic tests, potential treatments and better ways to predict the outcomes. Genomics technologies are central to this work, and analysis of the data generated by these technologies is reliant on substantial amounts of computing. Among others this is achieved on site through the use of a dedicated HPC facility housed in a machine room on site.


We are seeking an experienced Principal Software Architect to join our dynamic Scientific Computing Team. You will develop and implement bioinformatics analysis pipelines for personalised medicine based on the Snakemake workflow management system to support the analysis of large volumes of deep sequencing and other types of data. Pipelines will run on a 1’500 core HPC Linux cluster that resides in a dedicated data centre. The Scientific Computing Team provides a stimulating and motivating work environment, you will be encouraged and supported to keep track in this field.


About You:

You will have a PhD in Computer Science or Bioinformatics (or related discipline) or a relevant postgraduate degree in a related field plus significant relevant experience. You will also have a considerable depth of specialist programming knowledge, experience and skills, a familiarity with workflow development and data management and strong communication skills. You will also have experience with working in HPC environments and batch systems in particular. This role is an exciting opportunity to join a highly interdisciplinary team that combines biology with computer science, mathematics and software engineering, whose goal is to help understanding the cancer genome.


Although an understanding of cancer genomics and cell biology would be advantageous, it is not a prerequisite.

Our aim is to understand the fundamental basis of cancer and apply that knowledge to developing new treatment strategies for cancer patients.  Our advanced research programmes span a spectrum of cancer research, from the molecular and cellular basis of cancer through to drug discovery, translational research and clinical trials.

The Institute has access to outstanding laboratory facilities and exceptional core services, including next generation sequencing, microarrays, confocal microscopy, bioinformatics, histology and mass-spectrometry. 


Why choose Cancer Research UK Manchester Institute?

The Cancer Research UK Manchester Institute (www.cruk.manchester.ac.uk), an Institute of The University of Manchester (www.manchester.ac.uk), is a world-leading centre for excellence in cancer research.  The Institute is core funded by Cancer Research UK (www.cancerresearchuk.org), the largest independent cancer research organisation in the world. We are currently situated at the internationally-renowned life sciences campus at Alderley Park in Cheshire England, 15 miles from Manchester, a vibrant and dynamic city surrounded by beautiful countryside.


We are partnered with The Christie NHS Foundation Trust (adjacent to the CRUK MI Paterson Building) in South Manchester (www.christie.nhs.uk), one of the largest cancer treatment centres in Europe.  These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.


Additional Information:

On the 26th April 2017 The Paterson Building, which housed most of the Cancer Research UK (CRUK) Manchester Institute, caught fire resulting in significant damage. We shall be rebuilding our world-class research facilities and we would like to make you aware that in the meantime, the primary place of work for this position will be at the internationally-renowned life sciences campus at Alderley Park, which has excellent facilities to carry out research. We anticipate that this will be for a few years, after which we will return to our original site in Withington, Manchester, next to The Christie NHS Foundation Trust (Wilmslow Road, M20 4BX).

To apply for this position please follow the link below:


http://www.cruk.manchester.ac.uk/Opportunities/Opportunities-Home

Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies

Enquiries about vacancy shortlisting and interviews:

Manager: Dr Marek Dynowski,

Email: marek.dynowski@cruk.manchester.ac.uk

General enquiries:

Email: hrservices@manchester.ac.uk

Tel:      0161 275 4499

Technical support:

Email: universityofmanchester@helpmeapply.co.uk

Tel:      0161 850 2004

This vacancy will close for applications at midnight on the closing date

Further Particulars


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